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KMID : 0603820110170040337
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Journal of Experimental & Biomedical Science
2011 Volume.17 No. 4 p.337 ~ p.345
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Comparison of Renal Function and Clinical Outcomes between Diabetic and Non-diabetic Patients Underwent Off-Pump Coronary Artery Bypass Grafting Surgery
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Moon Seong-Min
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Abstract
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It is well recognized that conventional coronary artery bypass grafting (ONCAB) often leads to major organ dysfunction including renal injury. Diabetes mellitus is a major cause of nephropathy and poor clinical outcomes. The aim of this retrospective study was to evaluate the occurrence of adverse outcomes including renal impairment between diabetic (n=75, DM group) and non-diabetic patients (n=72, Non-DM group) underwent off-pump coronary artery bypass grafting surgery (OPCAB). Fasting glucose, hemoglobin A1c, fructosamine, fibrinogen and serum osmolality levels in the DM group were higher than those of the Non-DM group at pre-operative (Pre-OP) period (P＜0.05). History of hypertension and renal impairment in the DM group was higher than that of the Non-DM group (P＜0.05). Potassium (K?), blood urea nitrogen and creatinine levels were higher, whereas sodium (Na?) and glomerular filtration rate (GFR) levels were lower in the DM group than the Non-DM group at peri-operative period (P＜0.05). Fasting glucose levels at Pre-OP period had positive correlations with blood urea nitrogen and creatinine levels at peri-operative period, but negative correlations with GFR levels at peri-operative period in the DM group (P＜0.05). Incidences of renal impairment, diuretic therapy or continuous renal replacement therapy and fever in the DM group were higher than those of the Non-DM group at post-operative period (P＜0.05). These results suggest that blood glucose level should be tightly controlled at peri-operative period to avoid renal dysfunction in diabetic patients.
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KEYWORD
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Diabetes mellitus, OPCAB, Renal impairment, Clinical outcome
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